EC Number | Cloned (Comment) | Organism |
---|---|---|
5.1.3.14 | gene gneY, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparisons | Bacillus anthracis |
5.1.3.14 | gene gneYZ, DNA and amino acid sequence determination and analysis, genetic structure, sequence comparisons | Bacillus anthracis |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.3.14 | UDP-N-acetyl-alpha-D-glucosamine | Bacillus anthracis | - |
UDP-N-acetyl-alpha-D-mannosamine | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.3.14 | Bacillus anthracis | Q81K32 | - |
- |
5.1.3.14 | Bacillus anthracis | Q81X16 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.3.14 | UDP-N-acetyl-alpha-D-glucosamine | - |
Bacillus anthracis | UDP-N-acetyl-alpha-D-mannosamine | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.1.3.14 | bas5048 | - |
Bacillus anthracis |
5.1.3.14 | bas5117 | - |
Bacillus anthracis |
5.1.3.14 | GneY | - |
Bacillus anthracis |
5.1.3.14 | GneZ | - |
Bacillus anthracis |
5.1.3.14 | UDP-GlcNAc 2-epimerase | - |
Bacillus anthracis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.1.3.14 | evolution | Bacillus anthracis gneY and gneZ encode nearly identical UDP-GlcNAc 2-epimerase enzymes that catalyze the reversible conversion of UDPGlcNAc and UDP-ManNAc | Bacillus anthracis |
5.1.3.14 | physiological function | GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. Gene gneZ, but not gneY, is required for Bacillus anthracis vegetative growth, rod cell shape, S-layer assembly, and synthesis of pyruvylated secondary cell wall polysaccharide (SCWP). Nevertheless, inducible expression of gneY alleviates all the defects associated with the gneZ mutant. In contrast to vegetative growth, neither germination of Bacillus anthracis spores nor the formation of spores in mother cells require UDP-GlcNAc 2-epimerase activity. UDP-GlcNAc 2-epimerase enzymes have been shown to be required for the attachment of the phage lysin PlyG with the bacterial envelope and for bacterial growth. UDG-GlcNAc 2-epimerase activity, i.e., the expression of either gneY or gneZ, is not required for B. anthracis spore formation | Bacillus anthracis |